Sunday, November 8, 2009

What is breast cancer ?



Causes and Risk Factors Of breast cancer

I do not know the exact cause of breast cancer. Nevertheless, the research identified a number of factors that can increase the risk of certain individuals, which include ↓







→ Family history who have similar disease
→ Age a growing
→ Not having children
→ First pregnancy at age above 30 years
→ Menstrual period is longer (first menstruation early or late menopause)
→ Hormonal factors (both estrogen and androgen).

Of the risk factors mentioned above, family history and age of the most important factor. Family history who have had breast cancer increases the risk of developing this disease. The researchers also found that mutations of two genes BRCA1 and BRCA2 can increase the risk of cancer of women to 85%. 3 Interestingly, the genetic factor affects only 5-10% of breast cancer and this suggests that other risk factors play a role penting.4

Importance of age factor as risk factors are reinforced by data that 78% of breast cancers occur in patients over the age of 50 years and only 6% in patients less than 40 years. The average age at the time of the discovery of cancer is 62 tahun.4, 5

The study also evaluates the role of lifestyle factors in breast cancer development, including pesticides, alcohol consumption, obesity, fat intake and lack of physical though. 4.5


Diagnostic and Examination

A number of studies show that early detection of breast cancer, followed by therapy can increase life expectancy and provide more treatment options for patients.

An estimated 95% of women diagnosed with early stage breast cancer may survive more than five years after doctors diagnosed that many who recommend that women undergo 'aware' (check your own breasts) at home on a regular basis and suggested doing an annual routine examination to detect lumps in the breast. In general, breast cancer detected by patients themselves and usually a hard lump and small. In many cases these lumps do not hurt, but some women experience a cause of cancer pain.

In addition to physical tests, annual mammography or twice a year and a special ultrasound is recommended to detect breast abnormalities in elderly women and women at high risk of breast cancer, before cancer occurs. If the lump can be felt or abnormalities detected at mammography, a biopsy should be done to obtain tissue samples for testing under a microscope and examine the possibility of a tumor.

If the cancer is diagnosed, it is necessary to do a series of tests such as estrogen receptor status


New types of tests also include tests to determine the status of the tumor HER2 (human epidermal growth factor receptor-2). This relates to the growth of aggressive cancer cells. Patients said HER2-positive if the tumor was found overekspresi HER2 and less sensitive to certain chemotherapy. Cancer with HER2-positive is known as an aggressive form of breast cancer and have a travel sickness worse than patients with HER2-negative. An estimated 20% - 30% of patients with breast cancer have HER2-positive. HER2status




Breast Cancer Treatment

Management of breast cancer conducted with a series of treatments including surgery, chemotherapy, hormone therapy, radiation therapy and most recently the monoclonal antibody therapy. This treatment is intended to destroy or limit the spread of cancer and eliminate disease symptoms. The diversity of types of breast cancer requires a detailed diagnostic done before deciding which type of therapy will be used, so the choice is individual.



special tips from zone4health, food recommendations in the treatment of breast cancer

There are a few recommended foods to be consumed on a regular basis. Consumption may only be one type of material or a mixture of several ingredients. If we are attacked by breast cancer, it is recommended to drink the juice of ingredients below, do one glass twice a day.
1. Carrots
2. Radish
3. Plantain
4. Carambola sweet
5. Celery
6. Broccoli
7. Cabbage
8. Apple
9. Garlic
Soy milk drink half a glass, do two times a day, or 100 grams soy for consumption every day.

Green Vegetables variety Cancer Prevention:
1. Beans
2. Cassava leaves
3. Bean
4. Papaya leaf


Primary Systemic Therapy (Neo-adjuvant Therapy)

The selection of primary systemic therapy can be performed before the surgery making the tumor, this depends on the type, distribution and size of tumors at the time of initial diagnostic. This therapy aims to reduce tumor size to allow for the operation while keeping the breast form. It also provides valuable information about the sensitivity of tumors to the drug used. This information will determine the appropriate therapy to overcome the remaining tumor after surgery.


Surgery

Primary tumor is usually removed by surgery. Surgical procedures performed on breast cancer patients depending on disease stage, tumor type, age and general condition of the patient. The surgeon can lift the tumor (lumpectomy), raised some breast and
a lymph gland or removal of the entire breast (mastectomy). To increase life expectancy, surgery is usually followed by additional therapy (adjuvant) as radiation, hormones or chemotherapy.


Adjuvant Radiation Therapy
Radiation therapy is done by X-ray high-intensity to kill cancer cells that are not raised during the surgery. This was done in patients who have undergone surgery for a localized tumor in an area. Side effects on the skin include: itching, redness, dry skin and fatigue.

Hormonal therapy
Some breast tumors express many estrogen receptors (ER) on the cell surface. In this tumor type, female hormone estrogen which support tumor growth bind to RE and regulate cell growth cycle. Breast cancer that depend on estrogen-called RE-positive. Hormonal therapy like tamoxifen or aromatase inhibitors, inhibit the growth effects of estrogen and can be used as adjuvant therapy after surgery or at an advanced stage breast cancer (metastatic).

Chemotherapy
Chemotherapy drugs are used both at an early stage or advanced stage disease (can not do surgery, an advanced stage of localized or metastatic). Chemotherapy drugs can be used singly or in combination for treatment of breast cancer are:

Anthraycline example: doxorubicin, epirubicin
Taxane example: paclitaxel, docetaxel
Fluoropyrimidine example: capecitabine, 5-fluorouracil (5 - Fu)
Alkylating agent example: cyclophosphamide

Imunologik Therapy
Approximately 20-30% of breast tumors showing gene amplification overekspresi or excessive. For such patients, trastuzumab, an antibody specifically designed to attack HER2. Trastuzumab inhibits the growth of the tumor and kill tumor cells. Patients should also undergo tests to benefit HER2 therapy with trastuzumab, which is the only imunologik therapy for breast cancer therapy.



Treating Patients At End Stage Disease

Approximately 50% of patients with breast cancer can be cured, either with initial therapy or additional adjuvant therapy. For the other 50%, ie patients with metastatic, more treatment options aimed at improving life expectancy. Among the many cancer drugs studied, only slightly effective in cases of metastatic breast cancer patients, such as trastuzumab and capecitabine.

The focus of therapy in end-stage cancer is prolong life without reducing the quality of life of patients. In breast cancer patients with HER2-positive, trastuzumab given as first line therapy for metastatic breast cancer in combination with other chemotherapy drugs (eg, docetaxel or paclitaxel) was also in second-line or on the third line as a single therapy.


Reference

1. WHO 2003 (http://www.who.int/mediacentre/releases/2003/pr27/en/)
2. Perez EA. Current Management of metastatic Breast Cancer. Seminars in Oncology 1999; 21 (Suppl.7) :19-24.
3. Blackwood MA, Weber BL. BRCA1 and BRCA2: from molecular Genetics to Clinical Medicine. Lancet 1996; 347: 1643-1645.
4. Imaginis (http://www.imaginis.com/beasthealth/statistics.asp # 2)
5. Questions & Answers: Young Women and Breast Cancer. National Alliance of Breast Cancer Organizations. February 2000.


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38 comments:

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zone4health on November 8, 2009 at 10:08 PM said...

PERTAMAX !!!!!!!!!!!! :-j

yeah..... :-y smoga artikel ini bermanfaat....

hope this short article can be useful for you all....;;)

wassaLamu`aLaikum....

comment yah all... :-k thanks... :L

Piet Puu on November 8, 2009 at 10:55 PM said...

hmmm :D piet suka artikelnya.. :o
kemaren yg piet baca di Sardjito Hospital
lebih mengerikan lagi ka...,
katanya ga bole makan2 fast food... :-r
aduuu repott...
jadi mengkonsumsi fast sood berkurang sejak...

ADA KECOA ka...........
udaa pergi hee B-)

sejak baca artikel di Sardjito
nganterin ka2 sepu2ku jaga dokter dpt pengetahuan baru :E
ehh di sini di tambahin....
hmm ko piet jadi cerita :-e

irmasenja on November 9, 2009 at 1:43 AM said...

ass,...

apa kbr sob ?
maaf baru berkunjung,info tentang kankernya bgs bgt ^_^
trima ksh ya...

* oh ya widget tentang random ayat al-quran nya sudah aku pasang loh ^_*
sudah aku copas.
makasih ya...

^_^

cara hack facebook on November 9, 2009 at 11:09 PM said...

mmaf juragan baru bisa komen ne..
karena pakai basa bule..ane rada gak ngerti..
keknya mentebs gan..lanjutkan yah...

zone4health on November 9, 2009 at 11:43 PM said...

► ♥ Piet Puu ♥: hhah... :)) pake kecoa segala di sebutin....

hmm... alhmdllh bs mmnmbah pengthuannya... :)

► irma: yupz...
sama², alhmdllh... senang bisa membantu... :)

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blog buat bloggers on November 10, 2009 at 12:08 AM said...

mantap pengetahuannya sob, fakultas kedokteran ya sob, hehe....

nice info sob!!!!

Zahra Khusnul Lathifa on November 10, 2009 at 10:58 AM said...

wahh...infonya bermanfaat banget, terutama untuk kita perempuan :) thanks for sharing..

narti on November 10, 2009 at 11:47 AM said...

lengkap banget artikelnya, makasih ya.

Rizky Aditya on November 10, 2009 at 11:48 AM said...

mampir sambil baca2 sob :o

sda on November 10, 2009 at 11:48 AM said...

ternyata ada faktor keturunan juga ya?
makasih banget nih, artikelnya sangat bermanfaat.

ina on November 10, 2009 at 1:53 PM said...

muzti hati2 terhadap penyakit yg satu ini,
yg merupakan momok bagi setiap wanita...

good posting kakag
:L :L :L

blackberry application on November 10, 2009 at 9:06 PM said...

wah, bagus sekali templatenya. keren dan imut, hehehe

Osi on November 10, 2009 at 9:08 PM said...

Infonya cukup lengkap jg ya....

Kurniawan.q on November 10, 2009 at 9:13 PM said...

susu kedelai ya

masdani on November 10, 2009 at 9:25 PM said...

nice post, thanks for sharing..

flowers on November 10, 2009 at 11:52 PM said...

good information...

IYAN1982 on November 11, 2009 at 1:41 PM said...

Nice info friend keep it up

Piet Puu on November 11, 2009 at 1:49 PM said...

hmmm lagunya... nice beb... :o
wkwkwk... lebai mode ON :))
heee :x
piet suka.., syukron dear :o
miss u too :E

zone4health on November 11, 2009 at 10:43 PM said...

all: thanks banyak buat semua yang udah mampir dan meninggalkan comment... :-k
:o sy kan sring mampir ke tempat sobat.... :s

SeNjA on November 11, 2009 at 11:44 PM said...

berkunjung,....gak sopan nih sob,mengganggu waktu istirahatmu *_*

Rin on November 11, 2009 at 11:49 PM said...

waaah, infonya mantabs!!! :D
saia follow yah? :)

THE PAINTING PROPHETS HISTORY on November 12, 2009 at 5:16 AM said...

ASWW...SODAKOH RUTIN...
sahabat buku tamunya tolong perbaiki...

tembelek on November 12, 2009 at 7:37 AM said...

thanks for adding your information knowledge

Sadewa on November 12, 2009 at 8:50 AM said...

Informasi yang sangat berguna sekali neh shob terus semangat memberi informasi tentang kesehatan ya

Zahra Khusnul Lathifa on November 12, 2009 at 10:34 AM said...

nice info bro...izin follow yach, thanks!

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healthy on November 13, 2009 at 12:29 AM said...

nice info health for future every body

TÜRKİYE on November 13, 2009 at 5:43 AM said...

SELAM, İYİ GECELER.

Evan Ed Scence on November 13, 2009 at 6:39 AM said...

$jd kringatan neh baca neh postingan..
takut klo2 perempuanku terkena penyakit ginian
Semoga saja tidak..

trims infonya kawan..moga berguna sangat

Ada info ttg jantung g???

Lita Alifah on November 13, 2009 at 8:47 AM said...

hehehe :-r ndak ngeti bahasa inggris
ShoutMix nya ndak ada ya?:)

Pierre on November 13, 2009 at 11:16 AM said...

bro....buku tamunya koq gak bisa diisi ya? udah kandas ke bawah, tapi gak ketemu bagian untuk "shout"nya....

ina on November 13, 2009 at 11:25 AM said...

infonya lengkap kag,...
teruz posting yah!!!

Rossy R on November 13, 2009 at 1:31 PM said...

that Cancers attack to man too??

Bang Del on November 13, 2009 at 6:02 PM said...

Thanks for the nice and helpfull healthy blog.

Pierre on November 16, 2009 at 2:40 PM said...

monday visit

Dr. Economides on May 13, 2010 at 1:43 PM said...

Medical diagnosis of a breast cancer patient usually experience lump near the underarm or breast, a sudden change in breast size and bloody discharge from the nipple. It is really important for women to detect such symptoms to treat it accordingly as early as possible.

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